THE GENE REPERTOIRE OF THE MAIN CYSTEINE PROTEASE OF TRYPANOSOMA CRUZI, CRUZIPAIN, REVEALS FOUR SUB-TYPES WITH DISTINCT ACTIVE SITES

The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

Abstract Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.Encoded by a multigenic family, previous studies have estimated the presence of dozens of copies spread over multiple chromosomes in different parasite strains.Here, we describe the complete gene repertoire of cruz

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Agreement between retrospectively assessed health-related quality of life collected 1 week and 12 months post-injury: an observational follow-up study

Abstract Background Retrospective assessment of pre-injury health-related quality of life (HRQL) is frequently used to measure change from pre- to post-injury HRQL.However, retrospective measurement may be confounded by recall bias.It is Andrographis assumed that presence of recall bias is influenced by several factors, such as the measurement scal

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